Abstract

Introduction: An integrative review was conducted to elucidate epidemiological and clinical aspects surrounding alcohol-involved brain injury (TBI) victims, highlighting its dubieties around the theme, especially with regard to the Glasgow Coma Scale (GCS). Objectives: Expose the epidemiology and clinical aspects that may be distorted. Design and setting: Descriptive review conducted in João Pessoa, PB, Brazil. Methodology: This is an descriptive review, based on the question: TBI in alcoholic victims. A survey of studies published in the BVS and SciELO databases was conducted with a temporal focus between 2018 and 2020. Results: Epidemiological data were conclusive: most victims are male and young. Concerning the clinical aspects, the question that emerged was: is the evaluation by GCS of the alcoholic patient with suspicion of TBI accurate? The answer was negative. The use of the GCS was revealed to be inefficient, due to the reduction of motor and verbal response, which leads one to assume that it is motivated by alcohol. Additionally, alcohol in medium and high doses reduces blood pressure and elevates heart rate. These signs indicate the opposite of what is expected in a picture of intracranial hypertension caused by TBI. Such features disguise its severity. Conclusions: It is necessary to outline a better way of assessing TBI in this group and to ensure that only alcoholic libation is not associated with lower GCS numbering, preventing concealment of the severity of the trauma.

Highlights

  • Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack

  • The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells

  • Conclusion: the analyzed data indicate that the polymorphisms contributed to the susceptibility to Parkinson’s disease (PD), further studies related to the polymorphisms and their relationship to PD are still needed for more ethnic groups, and early diagnosis is possible

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Summary

Introduction

Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Methods: A literature review and an observational, descriptive and transversal data collect on treatment for acute demyelinating polyradiculoneuritis, available at DATASUS from January 2008 to December 2020, and articles available at Scielo and PubMed. Results: There were 7,917 hospitalizations, representing a total expenditure of R$ 9,392,552.04, 2009 being the year with the highest number of hospitalizations (809) and 2017 with the highest amount spent during the period (R$ 967,284.65). Methods: A literature review and an observational, descriptive and transversal data collect on surgical treatment was carried out, available from January 2008 to December 2020 and articles available in Scielo, Lilacs and PubMed. Results: There were 15,148 hospitalizations for surgical procedures for the treatment of chronic subdural hematoma, representing a total expenditure of R$ 45,365,258.21, with 2018 being the year with the highest number of hospitalizations (1,418) and with the highest amount spent during the period (R$ 4,570,334.28). Conclusions: The “Coca-Cola Bottle sign” is a classic sign of Graves’ disease, some signs, such as, unilateral and single orbital musculature involvement, may be suggestive of involvement by other etiologies, suggesting the benefit of an early expanded investigation

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