Abstract
Alcoholic Liver Disease (ALD) is still a major problem in Western and Asian countries. The long-term impact of ALD might further lead to liver disease complications, such as liver cirrhosis and liver cancer. The safe limit amount of alcohol might be different between Western and Asian countries as the genetic factor might also become an important role in the liver disease progression. It is well-known that alcohol consumption would have synergistic liver injury effect together with chronic viral hepatitis infection. However, in non-alcoholic fatty liver disease (NAFLD), mild to moderate alcohol consumption might have a beneficial effect as it might protect the liver. Further studies will be needed to confirm the beneficial effect of mild to moderate alcohol consumption for protecting the liver as the liver disease progression in many countries might have different influenced factors, especially in chronic viral hepatitis infection due to different genetic polymorphism and different virus genotype distribution. Obesity, which is now becoming one of the biggest problems in NAFLD patients, it would also give a different prognosis in liver disease progression between Western and Asian countries because of different type of food habits and lifestyle. Alcohol consumption issue would become the emerging controversies issue in the near future as NAFLD is now becoming an emerging disease despite chronic viral hepatitis infection.
Highlights
Alcoholism is still become a major problem either in Western countries or Asian countries, which responsible for 493.300 deaths and 14.544.000 disability adjusted life years (DALYs)
Alcoholic liver disease (ALD) is a spectrum from alcoholic steatosis, steatohepatitis, and liver cirrhosis which can further lead to the liver cancer development
There are several limit of alcohol amount intake and the length of the consumption itself that can lead to the development of alcohol steatohepatitis until the development of liver cirrhosis based on literatures
Summary
Alcoholism is still become a major problem either in Western countries or Asian countries, which responsible for 493.300 deaths and 14.544.000 disability adjusted life years (DALYs). Alcoholic liver disease (ALD) is a spectrum from alcoholic steatosis, steatohepatitis, and liver cirrhosis which can further lead to the liver cancer development. There are several limit of alcohol amount intake and the length of the consumption itself that can lead to the development of alcohol steatohepatitis until the development of liver cirrhosis based on literatures. The change of the lifestyle among young generation might be one of the important factors for the development of alcoholic liver disease. Based on an epidemiological study, looking at male-female differences in drinking and drinking related problems, the sociocultural influence can be an important role in alcoholic liver disease development [4]. There has been new paradigm about mild to moderate amount of alcohol consumption, where it is postulated that there might be an advantage for protecting the liver from liver disease progression. (NAFLD) has been shown with mild to moderate alcohol consumption [5]
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