Abstract
Adolescence is an important neurodevelopmental stage for brain sites that are related to the impulse control and reward systems. Alcohol abuse during this period may cause irreversible modifications of neural circuits that are linked to impulsivity. The present study evaluated the effects of alcohol ingestion during adolescence in Wistar rats on anxiety, risk-taking, and impulsive behavior parameters during adulthood. Male Wistar rats (n 40) were randomly assigned to 1 of 3 treatments: 0, 1, and 3 g/kg alcohol administered orally over 9 sessions, from postnatal Day 31 to 50. Anxiety and risk-taking behaviors were assessed in the elevated plus maze soon after adolescence and during adulthood, and impulsivity was assessed in the operant delay-discounting task in adulthood. None of the alcohol treatments altered risk-taking or impulsive behavior compared with the control group. The group that received 3 g/kg alcohol exhibited less anxiety-like behavior in the first exposure to the elevated plus maze compared with the control group. The results are discussed with regard to the doseresponse, frequency, duration, and age of exposure and route of administration.
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