Abstract
The prevalence of alcohol consumption is high among adult males during the reproductive period. The current study aimed to evaluate the impact of chronic administration ethanol on the quality of sperm in the rats. Twelve healthy Wistar male albino rats were randomly divided into 2 groups to represent the 2 phase duration. The first phase lasted 21 days and the second phase lasted 49 days. In each phase, the animals were separated into subgroups: A and B. Subgroup A represented control that received distilled water while subgroup B represented animals that received 7 mL.kgBW -1 of 30% ethanol per day, thrice a week. The data were analyzed using ANOVA (P<0.05). There is no significant difference in sperm concentration and viability. However, there is a significant difference in the motility of spermatozoa between the control group and ethanol-treated group. Thus, the study indicates that ethanol administration may disturb the sperm motility and have no clear effect on its concentration and viability. Keywords: alcohol consumption, reproductive function, sperm quality.
Highlights
INTRODUCTION1 Ethanol has been reported to be among the most widely abused drug which may suppress reproductive function and sexual behavior in laboratory animals and humans. Both acute and chronic ethanol administration exerts a dual effect on the hypothalamic-pituitary-gonadal axis by directly preventing testicular steroidogenesis and by inhibiting the release of Lutenizing Hormone-Releasing Hormone (LHRH) [1]
Ethanol enlarges oxidative stress through the generation of oxygen-free radicals and lipid peroxidation on its metabolism in the body [2], mainly because ethanol administration can cut down the antioxidant cells such as Superoxide Dismutase (SOD), Catalase (CAT), and Glutathione Peroxidase (GPx)
Reactive oxygen species result in lipid peroxidation in spermatogenic cell membranes which is the cause of cell apoptosis [5]
Summary
Twelve healthy Wistar male albino rats (average weight 280-340 g) were housed in the animal holdings of the Animal Physiology Laboratory, Faculty of Mathematics and Natural Sciences, University of Brawijaya, in well ventilated plastic cages with a 12/12 h light/dark cycle at 21-24°C and free access to rodent food and water. Approval for the study was obtained from the Animal Care and Use Committee of University of Brawijaya number 1079-KEP-UB. Thirty percent (30%) of ethanol prepared from absolute ethanol (99.86%) Smart Lab
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