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Abstract
Abstract. In man tolbutamide was shown to share certain properties with the drugs handled by the hepatic drug‐metabolizing system: its prolonged administration is capable of accelerating its own metabolism; the same effect is obtained by pretreatment with microsomal inducers such as phenobarbital, diphenylhydantoin and diazepam. — Chronic addiction to alcohol produces an enhanced rate of tolbutamide metabolism; on the other hand, prolonged treatment with tolbutamide is able to increase the rate of ethanol oxidation. The existence of a microsomal oxidation of ethanol supports the hypothesis that microsomes may be the site of the interference between alcohol and tolbutamide. — Additional evidence is provided by the observed inhibition of tolbutamide metabolism by ethanol infusion.
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