Year-end Sale % OFF 
Abstract
BackgroundThis study aimed to investigate the dose-response association between alcohol consumption and atrial fibrillation (AF) risk.MethodsPubMed, Embase, Cochrane Library, and Web of Science were systematically searched using keywords related to alcohol and AF from the establishment of databases up to 1 March 2021. Prospective studies examining the impact of alcohol on the risk of AF with hazard ratios (HRs) were included. Restricted cubic spline regression was performed to quantify the dose-response relationship between alcohol consumption and AF risk.ResultsThirteen eligible studies were included in the meta-analysis, with a total of 645,826 participants and 23,079 cases of AF. When compared with non-/seldom-drinkers, the pooled adjusted HRs of AF were 1.30 (95% confidence interval [CI]: 1.20–1.41) and 1.00 (95% CI: 0.96–1.05) for high and low alcohol consumption, respectively. Moderate alcohol intake significantly increased the risk of AF in males (HR, 1.21; 95% CI: 1.10–1.33) but not in females (HR, 1.02; 95% CI: 0.91–1.14). The cubic spline regression analysis illustrated that the risk of AF significantly increased with daily alcohol intake in a Non-linear manner (R2 = 0.64, P = 5.785 × 10−12).ConclusionThis study revealed a Non-linearly positive association between alcohol intake and the risk of AF. Low alcohol intake was not associated with the development of AF, whereas moderate alcohol intake significantly increased the risk of AF in males but not in females. Our meta-analysis highlighted that alcohol consumption should be restricted to a low level to reduce the risk of AF.
Highlights
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, which results in a 4- to 5- fold increased risk for stroke, tripling of the risk for heart failure, and 40–90% higher risk for all-cause mortality [1]
Clinical studies were eligible if they met the following inclusion criteria: [1] prospective cohort studies; [2] included only participants who were free of AF or atrial flutter (AFL) at baseline; [3] reported alcohol consumption as an exposure; [4] reported AF or a combination of AF/AFL as an outcome; [5] reported hazard ratios (HRs) with 95% confidence intervals (CIs) for at least three categories of alcohol consumption besides the reference group; [6] published in English
This study showed that high alcohol consumption was associated with a significantly increased risk of AF in both genders, which was consistent with previous studies [15,16,17,18]
Summary
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, which results in a 4- to 5- fold increased risk for stroke, tripling of the risk for heart failure, and 40–90% higher risk for all-cause mortality [1]. Previous studies have revealed multiple risk factors for AF, including older age, male sex, concomitant cardiovascular conditions, diabetes, and sleep apnea [2, 3]. Alcohol and Atrial Fibrillation outcomes, including cardiomyopathy, hypertension, stroke [4], and cancer [5,6,7]. Several studies suggested potential protective effects of low-to-moderate alcohol consumption on the cardiovascular system [8, 9]. Several previous studies indicated a Non-significant relationship between low-to-moderate alcohol drinking and AF development [12,13,14], but a recent community-based study found that a modest drinking level (12 g per day) was associated with a higher risk of AF [11]. This study aimed to investigate the dose-response association between alcohol consumption and atrial fibrillation (AF) risk
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
