Abstract
BackgroundAlcohol is a psychoactive substance with toxic and addictive properties. Biomarkers like GGT, AST, ALT and MCV are influenced by excessive ethanol consumption. Alcohol consumption represents a health risk and it has been linked to unemployment. The aim of this study how working status predict alcohol consumption through a cross sectional study comparing alcohol-related biomarkers levels in office workers and unemployed people.MethodsThis study includes 157 office workers and 157 unemployed people, who were recruited from January to December 2018. A propensity score matching procedure was applied to obtain two homogenous groups in terms of age and gender. A non-parametric analysis was performed on serum biomarkers that are generally altered by alcohol consumption. Logistic regression models were designed to evaluate how working status predict abnormal biomarker levels related with alcohol consumption.ResultsNo differences in median biomarker values were found between groups. Logistic regression analysis showed that office work is a negative predictor of pathological biomarker levels. Office workers had a significant relation with the levels of GGT (OR 0.48; 95% CI [0.28–0.84]), AST (OR 0.42; 95% CI [0.22–0.78]), ALT (OR 0.39; 95% CI [0.23–0.66]), and MCV (OR 0.37; 95% CI [0.19–0.70]).ConclusionOffice workers had lower absolute frequencies of pathological values of alcohol consumption biomarkers, after matching for age and gender compared with unemployed people. In addition, a significant negative association between office work is a negative predictor of biomarker levels of alcohol consumption. These results showed that work is an important determinant of health and that can represent a benefit for workers in terms of reducing the risk of consuming alcohol.
Highlights
Alcohol is a psychoactive substance with toxic and addictive properties
The levels of carbohydrate-deficient transferrin (CDT) are widely used to diagnose alcohol-related disorders in clinical, occupational and forensic contexts (Bortolotti et al, 2018; Helander et al, 2016) because it is an indicator for long-term alcohol consumption and, after discontinuing drinking, the serum Carbohydrate-deficient transferrin (CDT) levels usually normalize within approximately 2–4 weeks, but it may take even longer (Jeppsson, Kristensson & Fimiani, 1993)
Absolute frequencies of abnormal values of any biomarker were always lower among office workers
Summary
Alcohol is a psychoactive substance with toxic and addictive properties. Its consumption increases the risk for infectious diseases (Taylor et al, 2016; Rehm et al, 2017), noncommunicable diseases (Gao & Bataller, 2011; Roerecke & Rehm, 2010; O’Keefe et al, 2014; Klatsky, 2015), and injuries (Seedat et al, 2009; Mitra et al, 2017). Alcohol has direct toxic effects on all organs of the body, including the brain It is a psychoactive substance which causes addiction and its effects last for hours after consumption (Babor et al, 2010). The aim of this study how working status predict alcohol consumption through a cross sectional study comparing alcohol-related biomarkers levels in office workers and unemployed people. Office workers had lower absolute frequencies of pathological values of alcohol consumption biomarkers, after matching for age and gender compared with unemployed people. A significant negative association between office work is a negative predictor of biomarker levels of alcohol consumption These results showed that work is an important determinant of health and that can represent a benefit for workers in terms of reducing the risk of consuming alcohol
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