Alcohol consumption and breast cancer-specific and all-cause mortality in women diagnosed with breast cancer at the New York site of the Breast Cancer Family Registry.

Nur Zeinomar,Jasmine A Mcdonald,Mary Beth Terry,Ann J Cloud,Yuyan Liao,Ashley Thai,Amanda Ewart Toland

doi:10.1371/journal.pone.0189118

Nur Zeinomar, Jasmine A Mcdonald + Show 5 more

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https://doi.org/10.1371/journal.pone.0189118

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Abstract

PurposeAlcohol consumption is an established and important risk factor for breast cancer incidence in the general population. However, the relationship between alcohol and mortality among women with breast cancer is less clear. This study examines the effect of alcohol consumption on mortality in women affected with breast cancer at baseline from a high-risk family breast and ovarian cancer registry.MethodsWe studied 1116 women affected with breast cancer at baseline from the Metropolitan New York Registry. The examined reported alcohol consumption (total of beer, wine, liquor) was defined as the average number of drinks per week reported from age 12 to age at baseline. We assessed vital status of each participant using participant or family reported data and we used the National Death Index to supplement deaths reported through family updates. We used Cox proportional hazards models to estimate the association between alcohol intake and overall mortality (HRO), breast cancer-specific mortality (HRBC), and non-breast cancer mortality (HRNBC), adjusted for confounders.ResultsAfter a mean follow-up of 9.1 years, we observed 211 total deaths and 58 breast cancer deaths. Compared to non-drinkers, we found that both low and moderate to heavy levels of alcohol intake were not associated with greater overall mortality (≤3 drinks/week: HRO: 0.66, 95% CI: 0.38–1.14); > 3 drinks/week: HRO: 1.16, 95% CI: 0.85–1.58), breast cancer–specific mortality (≤ 3 drinks/week: HRBC:0.62, 95% CI: 0.19–2.03; >3 drinks/week: HR BC: 0.96, 95% CI: 0.49–1.89), or non-breast cancer-specific mortality (≤3 drinks/week: HR NBC: 0.73, 95% CI: 0.32–1.6; >3 drinks/week: HRNBC: 1.18, 95% CI: 0.75–1.86).ConclusionsAlcohol intake reported from age 12 to age at baseline was not associated with overall or breast cancer-specific mortality in this cohort of affected women with a family history of breast cancer.

Highlights

Alcohol consumption is associated with an increased risk of various cancers including oral, pharyngeal, esophageal, liver, colon and breast cancer[1]
Alcohol intake reported from age 12 to age at baseline was not associated with overall or breast cancer-specific mortality in this cohort of affected women with a family history of breast cancer
We investigated the association between alcohol consumption from age 12 until age at baseline and overall mortality, breast cancer-specific, and non-breast cancer mortality in women affected with breast cancer at baseline and explored differences across Hispanic/non-Hispanic ethnicity, age, body mass index (BMI), and estrogen/progesterone hormone receptor status

Summary

Introduction

Alcohol consumption is associated with an increased risk of various cancers including oral, pharyngeal, esophageal, liver, colon and breast cancer[1]. Studies on the association between alcohol consumption and mortality among those with a history of breast cancer have been less consistent. Three studies, including two large prospective cohorts have supported an association with alcohol intake and overall breast-cancer mortality [6,7,8]. Three prospective cohort studies by Harris et al (2012) (n = 3,146), Newcomb et al (2013) (n = 22,890), and Barnett et al (2008) (n = 4,560) found that post-diagnostic alcohol was not associated with breast cancer mortality [9,10,11]. Two prospective cohort studies by Hellmann (n = 528) and Fuchs (n = 85,709) found that 0.1–14.9g/day of alcohol intake was associated with a 4–33% decrease in the rate of breast cancer mortality [15, 16]. At a higher intake of >15 g/day, risk of death from breast cancer increased by 37–67%[15]

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