Abstract
Examination of mouse liver using biochemical and autoradiographic techniques has demonstrated a very transient rise in the synthesis of collagen and sulphated mucopolysaccharide in the sinusoidal walls following a single large dose of alcohol. Mice fed a diet with alcohol providing about one-third of the total energy intake often showed microscopic evidence of an increase in hepatic connective tissue. In no case did this progress to established liver cirrhosis. Similar techniques have been used to study human hepatic biopsy material in vitro. In chronic active liver disease including that occuring in alcoholics there is a notable increase in sulphated mucopolysaccharide synthesis while the collagen proline hydroxylase content of this tissue is also elevated.
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