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Abstract
Two abstracts, presented at the British Pharmacological Society conference in July, shed light on alcohol addiction. Alcohol craving can be triggered by environmental stimuli. Barry Everitt and colleagues have been studying this process and have demonstrated that the so-called ‘emotional brain’ or limbic system is involved. Intriguingly, they have identified a dopamine D3 receptor partial agonist that diminishes cue-controlled drug seeking. Another factor in the development of alcohol dependence is binge drinking. Crews and colleagues, studying CNS alterations associated with binge drinking, found that binge drinking resulted in the induction of many genes, including Fos and Ptgs2. Because adolescent drinking is a particular risk factor for alcohol dependence, the importance of age was also evaluated. CNS changes were found to be greater in the younger rats compared with their older relatives. KP
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