Abstract
The synthesis of the hydroxy-1-amino-3(5α) pregnane diastereoisomers and their fragmentation under electron impact has been described. The presence of an OH group in the position enhances the production of ions “a” of the amino-3 steroids (carbons No. 1, 2 and 3). This effect is particularly important in the case of the primary amines. Deuteriation experiments establish that the molecular ion of isomers bearing an axial OH group, rearrange into an “aldehyde” before fragmentation.
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