Albumin levels, mean platelet volume, and neutrophil lymphocyte ratio as predictors of COVID-19 outcomes

Abstract

Coronavirus Disease 2019 (COVID-19) is a respiratory infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. COVID-19 spreads very quickly to various countries and causes a high mortality rate. According to this urgency, a study was conducted on albumin levels, mean platelet volume (MPV), and neutrophil-lymphocyte ratio (NLR) as predictors of COVID-19 outcome. This research was an analytic observational study conducted cross-sectional at Dr. Moewardi Hospital Surakarta, Indonesia, from June-October 2021. Data analysis used the logistic regression test and ROC analysis to determine the cut-off point for each variable. The total samples used in this study were 123 samples, with 68 survival patients and 55 nonsurvival patients. Logistic regression test results received p values for MPV and NLR, respectively, 0.048 and 0.001, and OR values 1.369 and 1.186 with Nagelkerke R Square 0.186. The cut-off point of MPV is 9.05 (sensitivity 76.4%; specificity 48.5%; p=0.019), and the cut-off point of NLR is 3.27 (sensitivity 92.7%; specificity 55.9%; p=0.001). In conclusion, MPV and NLR can be used as predictors of COVID-19 outcomes.