Abstract
BackgroundThe evidence that albumin-bound paclitaxel (nab-paclitaxel) is safe and efficacious for the treatment of many types of malignant tumors is continuously increasing. However, the evidence and clinical data of nab-paclitaxel and gemcitabine in metastatic soft tissue sarcoma (STS) treatment are rare.MethodsThe clinical data of metastatic STS patients who received nab-paclitaxel/ gemcitabine chemotherapy between January 2019 and February 2020 were retrospectively analysed. All these patients were treated with nab-paclitaxel/ gemcitabine only after doxorubicin-based chemotherapy had failed. We evaluated the effectiveness and safety of nab-paclitaxel and gemcitabine in these patients.ResultsA total of 17 patients treated with nab-paclitaxel/ gemcitabine were enrolled in this study. One patient with angiosarcoma achieved complete response, 6 patients had partial response, 5 patients achieved stable disease, and 5 patients had progressive disease. The average diameter change in target lesion from baseline was − 19.06 ± 45.74%. And median progression free survival was 6 months (95% CI, 2–9 months). Grade 3 / 4 adverse events were not common, included neutropenia (17.6%), fatigue (11.8%), anemia (11.8%), leukopenia (11.8%), nausea (5.9%), peripheral neuropathy (5.9%), diarrhea (5.9%), and thrombocytopenia (5.9%). No treatment-related deaths occurred.ConclusionNab-paclitaxel/ gemcitabine combination chemotherapy is comparatively effective in the treatment of STS, demonstrates low toxicity, and is worthy of further study.
Highlights
The evidence that albumin-bound paclitaxel is safe and efficacious for the treatment of many types of malignant tumors is continuously increasing
Multi-target receptor tyrosine kinase inhibitors (TKIs) and programmed cell death protein 1 (PD-1) inhibitors have been shown to be effective against selective soft tissue sarcoma (STS), with a lower overall response rate (ORR) and median-PFS than those of doxorubicin and docetaxel/ gemcitabine [6, 7]
We retrospectively investigate patient outcomes and study the safety and effectiveness of nab-paclitaxel/ gemcitabine combination chemotherapy in STS treatment, with the aim of providing additional evidence to establish clinical study design and to support clinical treatment
Summary
The evidence that albumin-bound paclitaxel (nab-paclitaxel) is safe and efficacious for the treatment of many types of malignant tumors is continuously increasing. The evidence and clinical data of nabpaclitaxel and gemcitabine in metastatic soft tissue sarcoma (STS) treatment are rare. The first-line treatment for unresectable or metastatic STS is doxorubicin-based chemotherapy, with an expected overall response rate (ORR) of 11–26% and a median progression free survival (median-PFS) of 4–8 months [2, 3]. Docetaxel/ gemcitabine is another common chemotherapy regimen, often considered a second line treatment (after doxorubicin), with an expected ORR and an median-PFS similar to those of doxorubicin [4, 5]. Because of the limited ORR and median-PFS obtained with each of the above treatments, the overall survival for advanced STS is approximately only 16 months [8]. There is an urgent need for more effective drugs to treat STS
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