Abstract
Protein-based nanocarriers with inherent biocompatibility have been widely served as building blocks to construct versatile therapeutic nanoplatforms. Herein, bovine serum albumin-iridium oxide nanoparticles (denoted BSA-IrO2 NPs) are successfully synthesized via one-step biomineralization approach. The BSA-IrO2 NPs exhibits uniform size (40 nm), superb biocompatibility and high drug loading capacity for doxorubicin (27.4 wt%). Under near-infrared (NIR) laser irradiation, the as-prepared BSA-IrO2 NPs exhibited high photothermal conversion ability (54.3%) and good photostability. The in vitro drug release experiments displayed pH and NIR laser -triggered DOX release profiles, which could enhance the therapeutic anticancer effect. By utilizing this DOX loaded nanoplatform, effective synergistic chemo-photothermal therapy against human osteosarcoma can be realized, which has been systematically verified both in vitro and in vivo. Notably, in vivo pharmacokinetics studies showed that BSA-IrO2@DOX had prolonged blood circulation time due to the BSA component can improve the stealthiness of the nanoparticles during the blood circulation. Meanwhile, in vitro and in vivo toxicity studies demonstrated that the BSA-IrO2 NPs can act as biocompatible agents for drug delivery and cancer therapy. Therefore, this work presents a biomineralized iridium-based NPs with remarkable features and be used as a very potential therapeutic nanoplatform for cancer treatment.
Highlights
It is of great significance to fabricate an ideal therapeutic nanoplatform with prolonged blood circulation time and high drug loading efficiency
Experimental results were expressed as the mean ± standard deviation, and an analysis of variance (ANOVA) test was performed for statistical analysis. p < .05 was considered statistically significant (SPSS, Chicago, IL)
bovine serum albumin (BSA)-IrO2 NPs was prepared by incubating iridium ion (Ir3þ) with BSA in alkaline conditions through biomineralization process, where BSA acted as the stabilizer and template
Summary
Cancer becomes one of the primary hazards to human health worldwide. With the developments in our understanding of cancer biology, tremendous effective methods have been extensively explored for cancer therapy, including chemotherapy, radiotherapy, and surgery (Garg & Buchholz 2015; Landoni et al, 2017; Bray et al, 2018). It is of great significance to fabricate an ideal therapeutic nanoplatform with prolonged blood circulation time and high drug loading efficiency. Liu and coworkers successfully designed a multifunctional dual-responsive HSA-coated MnO2 nanoplatform through albumin-based biomineralization of Mn2þ to overcome tumor hypoxia-associated resistance of PDT, can be used for effective combination therapy (Chen et al, 2016a). The construction of all-in-one nanoplatform integrating metal oxide nanoclusters and another therapeutic agent via a biomineralization process strategy is favorable for enhancing anticancer efficiency. The resultant BSA-iridium oxide nanoparticles (BSA-IrO2 NPs) were used as a drug nanocarrier to load chemotherapeutic agent doxorubicin (DOX) for chemotherapy. The as-prepared BSA-IrO2@DOX NPs were used as a therapeutic nanoplatform for cancer chemo-photothermal synergistic therapy (Figure 1). This work presents a biomineralized iridium-based NPs as remarkable therapeutic nanoplatform with significant clinical values
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
