Albumin as an Adjuvant to Antibiotic Therapy in Non-SBP Infections in Patients with Chronic Liver Failure—A Prospective Randomized Study

Abstract

grip strength(kg/F). Bio impedance analysis: Fat%, Visceral fat%, Skeletal Muscle%. SGA A = well nourished. SGS B = mild to moderately malnourished, SGA C = severely malnourished. Results: Study Population: 70; Male 63%, Female 7%; CTP A 15, CTP B 22, CTP C 33. Prevalence of Hepatic Encephalopathy 22%, SBP 40%, and UGI bleed 24%. Prevalence of Malnourishment according to SGA score was 77% (22% severely malnourished). There was significant decrease in Handgrip strength, Mid Arm Muscle Circumference, Triceps skin fold thickness, Albumin level, visceral fat and BMI in malnourished patients. Significant increase in prevalence of HE (P = 0.002) and SBP (P = 0.0002) was noticed with malnourishment (SGA B and C), but risk of UGI bleed with malnourishment is not significant (P = 0.19). Reference values of MAMC, TSFT, Handgrip Strength in Healthy Subjects is 31.2 cm, 12.75 mm, 54.5 kg/F respectively. Conclusion: Bedside Nutritional assessment parameters are validated in this study to diagnose malnourishment in cirrhosis. Risk of spontaneous bacterial peritonitis and hepatic encephalopathy is high in malnourished cirrhosis patients. Nutritional assessment parameters can be used to risk stratify morbidity in cirrhosis.