Abstract
Key summary pointsAimTo investigate the association between albumin and C-reactive protein during acute hospitalization with functional and body composition parameters in patients admitted to geriatric rehabilitation.FindingsLower average albumin, higher albumin variation and lower minimum albumin were associated with larger declines in physical function during acute hospitalization and with lower functional and body composition parameters at geriatric rehabilitation admission. C-reactive protein, was only partly associated with lower gait speed at geriatric rehabilitation admission.MessageInflammation during acute hospitalization, especially lower albumin concentrations, relates to declined physical function and low functional and body composition parameters upon geriatric rehabilitation admission.
Highlights
Acute hospitalization influences muscle homeostasis and physical function negatively [1–3]
Dashed arrows indicate the variation of albumin and C-reactive protein concentrations had experienced a fall in the preceding year
Compared to the most favorable cluster, the least favorable cluster with high albumin variation and high average C-reactive protein (CRP) showed a larger decline in activities of daily living (ADL) and a lower gait speed (GS). This is the first study to investigate the association of acute inflammation during acute hospitalization with changes in ADL, GS, handgrip strength (HGS) and skeletal muscle mass index (SMI) in patients admitted to geriatric rehabilitation
Summary
Acute hospitalization influences muscle homeostasis and physical function negatively [1–3]. Acute systemic inflammation, characterized by low albumin and high C-reactive protein (CRP) serum levels, is often observed in acutely ill hospitalized patients and can contribute to high levels of muscle wasting [7]. This inflammation can lead to a catabolic state [8], which in turn can cause muscle degeneration through myonuclear apoptosis, alterations in muscle protein turnover and impaired satellite cell function [7, 9, 10]. Lower levels of albumin and higher levels of CRP are associated with a decline in ADL, gait speed (GS), handgrip strength (HGS) and skeletal muscle mass index (SMI) after 5–10 years of follow-up in community-dwelling older adults [21–26]
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