Abstract
Influence of total parenteral nutrition and operation on alanine turnover and venous alanine concentration was determined in 5 patients with stomach carcinoma using single injection technique of U- 14C alanine. Every patient served as his own control. In the postabsorptive state alanine turnover was 1.63 ± 0.31 mgatC · min −1, not different from a control group (1.84 ± 0.60 mgatC · min −1); during total parenteral nutrition alanine turnover increased to 3.21 ± 0.5g mgatC · min −1 with a rise in alanine concentration from 0.96 ± 0.17 mgatC · L −1 +0.69 ± 0.22 mgatC · L −1. After surgery during the same total parenteral nutrition alanine turnover increased further to 3.78 ± 0.17 mgatC · min −1 with a lowering of alanine concentration to 1.44 ± 0.22 mgatC · L −1. The present results show the distinct influence of TPH on alanine kinetics. The present data indicate that alanine turnover cannot be deduced from blood alanine concentration.
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