Abstract
Acute kidney injury (AKI) was defined by RIFLE and AKIN criteria a few years ago. These criteria can be easily clinically applied, have been validated and are used worldwide. In addition these criteria permit classification of the severity and valid epidemiology data of AKI. AKI is the most frequent acute renal condition and substantially increases morbidity and mortality statistically independent of comorbidities. As no therapy for AKI is available early prevention is critical. Therefore, new biomarkers for the early detection of AKI are required. This review covers current definitions, epidemiology and diagnosis of AKI especially with respect to new biomarkers.
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