Akut Alt Solunum Yolu Enfeksiyonu Nedeni ile Yatırılarak İzlenen Yenidoğanların Klinik ve Virolojik Özellikleri

Abstract

Aim: Viruses including respiratory syncytial virus, parainfluenza virus, rhinovirus are the primary etiologic agents in acute lower tract infections in neonates. We aimed to evaluate the clinical and demographic characteristics of newborns with acute lower tract infections. Material and Method: Data was recorded from patients' medical records admitted between January 2013 and April 2016. Results: The study population consisted of 43 neonates (19 girls, 24 boys). Mean gestational age and birthweight were 32 ± 4.4 weeks and 1735 ± 820 g, respectively. On admission, mean postnatal day and postmenstrual ages were 61 ± 48 days and 41 ± 4.3 weeks. Respiratory syncytial virus (n:8), rhinovirus (n:3), parainfluenza-3 virus (n:3) and adenovirus (n:3), respiratory syncytial virus and parechovirus (n:1), respiratory syncytial virus and adenovirus (n:1), rhinovirus and human bocavirus (n:1) were detected by polymerase chain reaction 20 patients in total. Siblings in the house (n:31), viral infection in the family (n:23), insufficient breastfeeding (n:15), bronchopulmonary dysplasia (n:13), siblings attending school (n:10) and being twin or triplet (n:7) were leading risk factors. Median hospital stay was 9 (1-60) days. Prematurity, fever, rales, respiratory support and feeding difficulty were statistically more common in polymerase chain reaction positive patients. Patients with the respiratory syncytial virus had higher gestational age, birth weight, less respiratory distress syndrome, surfactant use and patent ductus arteriosus, and lower postnatal day on admission than patients with other viruses (p<0.05). Conclusion: Respiratory syncytial virus is the commonest cause of acute lower tract infections in newborns, but the clinical importance of co-infection and rare agents such as human bocavirus and parechovirus should be kept in mind. Supportive management is the mainstay of the therapy.