Abstract
Hyperuricemic is a condition in which uric acid level in blood exceeds its normal level. Empirically, African leaves (Vernonia amygdalina Delile.) were used to treat diabetic, hypercholesterolemic, fever, hypertension and hyperuricemic by drinking boiled water of African leaves. This in vivo study was performed to determine antihyperuricemic activity of ethanolic extract of African leaves on male mice using the POCT (Point of Care Testing) method. Suspension combination of melinjo and chicken liver juice were used as hyperuricemic inductor. It is given orally for consecutive 9 days and the uric acid level were tested on day 1, 3, 6, and 9. The results showed that the ethanolic extract of African leaves (Vernonia amygdalina Delile.) at dosage 100, 200, and 400 mg/KgBW had a significantly different antihyperuricemic activity against negative control.
Highlights
Hyperuricemic is a condition in which uric acid level in blood exceeds its normal level
The results showed that the ethanolic extract of African leaves (Vernonia amygdalina Delile.) at dosage 100, 200, and 400 mg/KgBW had a significantly different antihyperuricemic activity against negative control
Effect of ethanol/water solvent on phenolic profiles and antioxidant properties of beijing propolis extracts
Summary
Antihyperuricemic Activity of Ethanol Extract of African Leaf (Vernonia mygdaline Delile.) on Swiss Webster White Mice Induced by Melinjo and Chicken Liver Juice. Abstrak Hiperurisemia adalah suatu kondisi dimana terjadi peningkatan kadar asam urat di dalam darah melebihi batas normal. Daun Afrika (Vernonia amygdalina Delile.) secara empiris digunakan masyarakat untuk pengobatan diabetes, hiperkolesterolemia, demam, hipertensi dan asam urat dengan cara meminum rebusan daun Afrika. Penelitian in vivo ini bertujuan untuk mengetahui aktivitas antihiperurisemia ekstrak etanol daun Afrika pada mencit jantan dengan metode POCT (Point Care of Testing). Penginduksi hiperurisemia yang digunakan adalah kombinasi suspensi melinjo dan jus hati ayam secara oral selama 9 hari berturut-turut dan kadar asam urat diukur pada hari ke 1, 3, 6 dan 9. Hasil penelitian menunjukkan bahwa ekstrak etanol daun Afrika (Vernonia amygdalina Delile.) dosis 100, 200, dan 400 mg/KgBB memiliki aktivitas antihiperurisemia yang berbeda bermakna terhadap kontrol negatif. Kata Kunci: Anti hiperurisemia, Vernonia amygdalina Delile, POCT
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