Abstract
Diabetes mellitus is a disorder of carbohydrate metabolism characterized by high blood glucose levels, or hyperglycemia. Hyperglycemia is a condition where the amount of glucose in the blood exceeds normal limits. Many plants that have the potential as the lowering of blood glucose levels, one of which pandan leaves (Pandanus amaryllifolius). The purpose this study were to identified class of chemicals compounds contained in extracts of water and hexane pandan leaves. Beside that, this study was conducted to determine the activity extracts of water and hexane pandan leaves to decrease blood glucose levels of white rats (Rattus novergicus) with hyperglycemia. Simplicia of pandan leaves extracted by maceration method. Condensed extract contains compounds defined and tested in vivo in rats induced by alloxan. Water extract of pandan leaves (EADP) contained alkaloids, flavonoids, saponins and tannins. Hexane extract of pandan leaves (EHDP) contained alkaloids and steroids. Measurement of blood glucose levels were measured by using a glucometer for 15 days with intervals in every 3 days. Negative control treatment with Na-CMC 1% was increased in blood glucose levels to 137.50%. Metfomin as positive control treatment with 9 mg could decrease the blood glucose levels to 66.41%. Treatment with EADP 300, EADP 600, EHDP 300 and EHDP 600 could decrease glucose levels 42.38, 60.25, 26.99 and 24.81% respectively. Therefore, water and hexane extracts of pandan leaves (Pandanus amaryllifolius) could decrease the blood glucose levels with in vivo.
Highlights
Pengobatan tradisional sebagian besar menggunakan ramuan yang berasal dari tumbuh-tumbuhan baik berupa akar, batang, biji, bunga, daun, ataupun kulit kayu
Diabetes mellitus is a disorder of carbohydrate metabolism characterized by high blood glucose levels
Many plants that have the potential as the lowering of blood glucose levels
Summary
Diabetes mellitus adalah salah satu gangguan metabolisme karbohidrat yang ditandai dengan tingginya kadar glukosa darah atau hiperglikemia. Banyak tanaman yang berpotensi sebagai penurun kadar glukosa darah, salah satunya daun pandan (Pandanus amaryllifolius). Tujuan dari penelitian adalah mengidentifikasi golongan senyawa kimia yang terkandung dalam ekstrak air dan heksana daun pandan serta menentukan aktivitas ekstrak air dan heksana daun pandan terhadap penurunan kadar glukosa darah tikus putih (Rattus novergicus) dengan hiperglikemia. Perlakuan kontrol negatif dengan Na-CMC 1% meningkatkan kadar glukosa darah sebesar 137,50%. Perlakuan kontrol positif dengan metfomin 9 mg menurunkan kadar glukosa darah sebesar 66,41%. Perlakuan dengan pemberian EADP 300, EADP 600, EHDP 300 dan EHDP 600 dapat menurunkan kadar glukosa berturut-turut sebesar 42,38, 60,25, 26,99 dan 24,81%. Ekstrak air dan heksana daun pandan (Pandanus amaryllifolius) dapat menurunkan kadar glukosa darah secara invivo. Kata kunci : antihiperglikemia, glukosa darah, in vivo, maserasi, Pandanus amarylliforius
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
