Abstract
Background: Aktisor® is a glycerol-based suspension which contains honey derived from Acacia, xanthan gum, and tannin-rich plant extracts from Alchemilla vulgaris (lady’s mantle) and Mimosa tenuiflora (jurema). High levels of certain matrix met-alloproteinases (MMPs) play a role in chronic wounds by constantly degrading the extra-cellular matrix (ECM) and thus preventing cell attachment and cell growth. Besides, tissue inhibitors of metalloproteinases (TIMPs) fail in the neutralization of MMPs. In addition to human MMPs, bacterial proteases have been found to influence tissue breakdown in infected wounds. Thus protease modulators are of a major importance and chronic wound treatment based on them is under active research. Objectives: The goal of the study was to evaluate the efficacy of dressings based on Aktisor® suspension in the treatment of chronic ulcers. Methods: Six patients with chronic ulcer [mean duration 1 year 5 months, (2 - 48 months)] who had received other than Aktisor® based treatment with no improvement over four weeks were included in this experiment. Results: Six patients experienced complete healing of their chronic ulcers. Conclusions: Aktisor® improved chronic wound healing and all the studied wounds healed after Aktisor® suspension was applied. Combination of tanninrich plant extracts and honey might bring synergy thus adding bactericidal properties. This pilot study encourages for further studies.
Highlights
A chronic wound is one that has not progressed through all the wound healing stages—hemostasis, inflammation, proliferation, and tissue remodeling or resolution—necessary for the healing to become complete and ends up in a pathological stage of inflammation [1]
Aktisor® is a glycerol-based suspension which contains honey derived from Acacia, xanthan gum, and tannin-rich plant extracts from Alchemilla vulgaris and Mimosa tenuiflora
The published data on tannins and wound healing are surprisingly scant even though herbal medicines have been widely used around the world since ancient times
Summary
A chronic wound is one that has not progressed through all the wound healing stages—hemostasis, inflammation, proliferation, and tissue remodeling or resolution—necessary for the healing to become complete and ends up in a pathological stage of inflammation [1]. Most of the evidence-based treatments for chronic ulcers have focused on a certain type of intervention such as compression therapy for oedema or systemic treatment of venous ulcers with pentoxifylline [4]. Most patients with a chronic wound have multiple etiologies for their wound [5]. Objectives: The goal of the study was to evaluate the efficacy of dressings based on Aktisor® suspension in the treatment of chronic ulcers. Methods: Six patients with chronic ulcer [mean duration 1 year 5 months, (2 - 48 months)] who had received other than Aktisor® based treatment with no improvement over four weeks were included in this experiment. Combination of tannin-rich plant extracts and honey might bring synergy adding bactericidal properties. This pilot study encourages for further studies
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
