Akrep Sokmalarında Oksidant ve Antioksidantların Değerlendirilmesi

Abstract

Objective: The purpose of this study is to evaluate the variations of pre- and post-treatment antioxidant status (TAS) and oxidant status (TOS) levels in scorpion envenomation, and of oxidative stress index (OSI) calculated with these levels. Material and Methods: Forty-four cases of scorpion envenomation who applied to Gaziantep University Medical Faculty Emergency Clinic between May 2009 and October 2010, and a control group of 20 volunteers, were enrolled to the study. Whole blood, biochemistry, coagulation parameters, and blood samples for toxin-antioxidant (TAS-TOS) study were obtained from patients (at the time of arrival and at the next control) and the control group. Erythrocyte packages were prepared for TAS-TOS study. Serum, plasma and erythrocyte packages were prepared for each patient at the first application and at the control after one month, and stored under -80o in the freezer. Results: No correlation was observed between age and gender and the levels of TAS, TOS, or OSI. TAS, TOS, and OSI levels in the first application were higher than the control levels taken one month later. TAS, TOS, and OSI arrival levels were higher than healthy control group levels. In patients who received scorpion serum, both arrival and control levels of TAS, TOS, and OSI were higher than those of patients who did not receive scorpion serum. TAS, TOS, and OSI levels in patients who were stung at more then one site were higher. Conclusion: Patients who received or did not receive scorpion antivenom were improved, and TAS, TOS, and OSI levels regressed. The significant increase in TOS and OSI levels in patients who received scorpion serum was not experienced in TAS levels.