Abstract
Gut microbiota is found to be associated with metabolic diseases. Many studies have shown that the colonization of Akkermansia.muciniphila(A.muciniphila) can reduce the permeability of intestinal barrier, which effectively prevent the occurrence of chronic low-grade inflammation, and is closely related to glucose metabolism, lipid metabolism and amino acid metabolism. The abundance of A. muciniphila in patients with diabetes, obesity and other metabolic diseases is decreased, and the metabolic state is improved after supplementation.A correct understanding of the relationship between A. muciniphila and metabolic diseases as well as mechanism will help to provide new targets and ideas for the treatment of metabolic diseases such as obesity and diabetes. Key words: Gut microbiota; Akkermansia.muciniphila; Diabetes mellitus; Obesity
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