Abstract
Uterine fibroids are dependent, in part, on sex steroids for growth. Consistent with a role of progesterone in fibroid growth, anti-progestins cause a durable reduction in fibroid size; yet, the mechanism by which anti-progestins exert this effect is unclear. Leiomyoma cells overexpress AKAP13, an A-kinase anchoring protein that augmented activity of estrogen and glucocorticoid receptors. However, it is not known whether AKAP13 affects progesterone action. Here we tested the hypothesis that AKAP13 augmented ligand-dependent progesterone receptor activity in fibroid cells.
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