Ajwa Date (Phoenix dactylifera L.) Ethanolic Extract Ameliorates Oxidative Stress in Rats: Alzheimer’s Disease Model

Abstract

Background: Alzheimer’s is a degenerative disease that results in decreased memory and cognitive function. The pathogenesis of Alzheimer’s disease is related to oxidative stress, which can promote damage to the brain. One of the natural ingredients that can be used as a treatment for Alzheimer’s disease is Ajwa dates. Ajwa dates contain lots of phytochemical compounds that act as antioxidants, providing a repair effect against disease.Objective: This study aimed to analyze the effect of dose and duration of Ajwa date extract administration on MDA (malondialdehyde) and SOD (superoxide dismutase) levels in Alzheimer’s model rats.Materials and Methods: Male Sprague Dawley rats, weighing 150-200 g, were orally given Ajwa date extract at dose of 200, 400 and 800 mg/kg body weight/day after the injection of homocysteine. MDA and SOD levels were measured before treatment, day seven and day 14. Data were then analyzed using the Oneway Anova test.Results: The group of Alzheimer’s rats that received Ajwa date extract for seven and 14 days experienced a decrease in MDA levels along with an increase in SOD levels compared to the control group. The group with highest doses had the same effect as the donepezil group on decreasing MDA levels and increasing SOD levels on day 14.Conclusion: Ajwa date fruit extract administration can reduce MDA levels and increase SOD levels in Alzheimer’s model rats. Ajwa dates have the potential for the treatment of Alzheimer’s disease.International Journal of Human and Health Sciences Vol. 05 No. 04 October’21 Page: 435-440