Abstract
Pulmonary function was studied in 28 asymptomatic subjects, 9-18 years with a history of laryngotracheobronchitis (croup) at least 5 years previously. The subjects were separated into 2 groups, croup--no allergies (CNA) and croup--allergies (CA), based on allergy history, skin tests, and eosinophil counts. A control group of 10 children was also studied. Lung volumes, peak expiratory flow rates (PEFR), forced expiratory volume in 1 second (FEV1), maximum mid-expiratory flow (MMEF), and maximum flow at 25% and 50% of the vital capacity (Vmax25 and Vmax50) were measured pre and post-exercise and post-isoproterenol inhalation. The response of flow rates to a helium-oxygen gas mixture was also measured. Baseline flow rates did not differ amoung the 3 groups. The table shows the number with >10% drop in flow rates post-exercise: Changes in PEFR, Vmax50 and Vmax25 for the CA and CNA groups were significantly different from normals at p <.05. None of the subjects had a history of exercised-induced bronchospasm and only 4 had a history of wheezing. This data suggests that patients with a past history of croup have normal resting bronchomotor tone but have an increased prevelance of both large and small airway hyperreactivity, which occurred irrespective of allergies.
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