Abstract
Seven cats were ventilated with intermittent positive pressure ventilation (IPPV) at 15 and 60 b.p.m. without and with superimposed oscillations (SO), before and after lung injury. The lung was injured by instillation of xanthine oxidase (xo) into the airways. Comparisons were made at inhibition of inspiratory activity (phrenic nerve). Before lung injury airway pressures were lower during IPPV without SO at 60 b.p.m. than at 15 b.p.m. (p<0.02). Before lung injury SO lowered airway pressure during IPPV at 15 b.p.m. (p<0.05). After lung injury airway pressures were lower during IPPV at 60 b.p.m. than at 15 b.p.m. with and without SO (p<0.05). After lung injury SO did not lower airway pressure during IPPV at 15 or 60 b.p.m. Arterial PCO2 was always lower after than before lung injury (p<0.1 - 0.01) at inhibition of inspiratory activity. We conclude that SO lowers airway pressure during IPPV at low frequencies but not at high frequencies. After lung injury SO does not lower airway pressures. The lower PCO2 necessary to inhibit inspiratory activity after lung injury may indicate an altered inhibitory input to the respiratory center.
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