Abstract
An understanding of the relationship between closing capacity (CC) and functional residual capacity (FRC) is central to the recognition, prevention, and management of small airway closure in anaesthesia and intensive care. Their relative magnitude determines whether significant airway closure occurs during the respiratory cycle, which in turn affects blood oxygen partial pressure. Alveoli that remain closed during the respiratory cycle may collapse and cause intrapulmonary shunt. Some airways may intermittently open and close during each breath; this is known as cyclic airway closure.
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