Abstract
Background: Very little is known about allergic contact dermatitis (ACD) from preimpregnated epoxy products (prepregs). Objective: To describe a patient with occupational ACD from prepregs, and report new quantitative data on the content of prepregs. Methods and Results: A laminator developed work-related vesicular hand dermatitis. He worked in an aircraft plant assembling aircraft parts, being exposed to preimpregnated carbon fiber and fiberglass sheets (prepregs), and epoxy adhesive tapes and foams. Triglycidyl-p-aminophenol (TGPAP; 1–0.25%, 2+; 0.05%, 1+) and tetraglycidyl-4,4`-methylene dianiline (TGMDA; 1%, 3+; 0.5–0.05%, 2+) provoked allergic patch test reactions, whereas o-diglycidyl phthalate was negative (1–0.05% pet) and standard epoxy provoked a weak (?+) reaction. Six prepreg products provoking allergic patch test reactions were analyzed for their TGPAP, TGMDA and diglycidyl ether of bisphenol A (DGEBA) content using gas and liquid chromatographic methods, showing up to 10% of TGPAP, 19% of TGMDA and 5% of DGEBA in the prepregs. An epoxy primer contained 61% of TGPAP. Conclusion: TGPAP and TGMDA caused occupational ACD. These chemicals need to be used when patch testing patients are exposed to prepregs, because patch testing with DGEBA may be negative.
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