Abstract
Partition coefficients, K fat, from air to human fat and to rat fat have been collected for 129 volatile organic compounds, VOCs. A linear free energy relationship, LFER, correlates the 129 values of log K fat with R 2 = 0.958 and a standard deviation, S.D., of 0.194 log units. Use of training and test sets gives a predictive assessment of around 0.20 log units. Combination of log K fat with our previously listed values of log K blood enables blood/plasma to fat partition coefficients, as log P fat, to be obtained for 126 VOCs. These values can be correlated with R 2 = 0.847, S.D. = 0.304 log units; the latter is also our assessment of the predictive capability of the LFER. Values of log P fat have been collected for 46 drugs, and can be fitted to an LFER with R 2 = 0.811 and S.D. = 0.355 log units. Unlike partition into brain or muscle, the data for VOCs and drugs cannot be combined. There are marked discrepancies for PCBs for which partition from blood/plasma into fat is very much less than that calculated from the data on VOCs or from the data on drugs.
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