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Abstract
All bio-containment guidelines and inspection documents set requirements for airtight containment boundaries around biohazards. Current international containment guidelines only scratch the surface for biosafety level 3 (BSL-3) and the available tests proposed are not entirely suitable for such facilities. Some steps in the right direction have been taken, notably as outlined in the standards put forth in the Australia-New Zealand model for their Physical Containment 3 designation.
Highlights
All bio-containment guidelines and inspection documents set requirements for airtight containment boundaries around biohazards
Current international containment guidelines only scratch the surface for biosafety level 3 (BSL-3) and the available tests proposed are not entirely suitable for such facilities
There are several reasons why airtight containment boundaries are required, the most obvious of which is that they prevent the escape of airborne biohazards
Summary
All bio-containment guidelines and inspection documents set requirements for airtight containment boundaries around biohazards. There are several reasons why airtight containment boundaries are required, the most obvious of which is that they prevent the escape of airborne biohazards. Methods to validate the air leakage of a containment boundary can be classified into two main categories: qualitative and quantitative. The Pressure Decay Test is an extreme test in that it represents the highest standard for room integrity in the U.S and Canada. It is designed for BSL-3Ag/BSL-4 containment construction validation, which is historically constructed with specialized and very expensive high performance containment barrier systems. That is pretty sound logic overall, but the devil is in the details and in how one records those details in the course of a construction project
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