Air Passenger Travel and International Surveillance Data Predict Spatiotemporal Variation in Measles Importations to the United States.

Marya L Poterek,Alexander Watts,Kamran Khan,T Alex Perkins,Moritz U G Kraemer

doi:10.3390/pathogens10020155

Abstract

Measles incidence in the United States has grown dramatically, as vaccination rates are declining and transmission internationally is on the rise. Because imported cases are necessary drivers of outbreaks in non-endemic settings, predicting measles outbreaks in the US depends on predicting imported cases. To assess the predictability of imported measles cases, we performed a regression of imported measles cases in the US against an inflow variable that combines air travel data with international measles surveillance data. To understand the contribution of each data type to these predictions, we repeated the regression analysis with alternative versions of the inflow variable that replaced each data type with averaged values and with versions of the inflow variable that used modeled inputs. We assessed the performance of these regression models using correlation, coverage probability, and area under the curve statistics, including with resampling and cross-validation. Our regression model had good predictive ability with respect to the presence or absence of imported cases in a given state in a given year (area under the curve of the receiver operating characteristic curve (AUC) = 0.78) and the magnitude of imported cases (Pearson correlation = 0.84). By comparing alternative versions of the inflow variable averaging over different inputs, we found that both air travel data and international surveillance data contribute to the model’s ability to predict numbers of imported cases and individually contribute to its ability to predict the presence or absence of imported cases. Predicted sources of imported measles cases varied considerably across years and US states, depending on which countries had high measles activity in a given year. Our results emphasize the importance of the relationship between global connectedness and the spread of measles. This study provides a framework for predicting and understanding imported case dynamics that could inform future studies and outbreak prevention efforts.

Highlights

We found that the inflow variable with full detail about air travel data and international surveillance data was associated with a high correlation between predicted and observed imported cases (0.84), which increased slightly when state-year combinations with zero imported cases were omitted (0.85) (Table 1)
Through regression of imported measles cases against multiple inflow variables, our analysis demonstrated the utility of air travel data and international surveillance data for predicting spatiotemporal variation in imported measles cases in the US
Inspection of our model’s predictions with respect to state, year, and likely country of origin showed that predictions of imported cases in a given state and year depended on the state’s population, the countries with which that state was linked via air travel, and contemporaneous measles activity in the countries with which it was most strongly linked

Summary

Introduction

Despite the elimination of endemic measles in the United States in the 1990s, the number of measles cases and outbreaks has begun to rise in recent years, as measles–mumps–. Measles virus is highly infectious and can cause serious symptoms and even death, and cases imported to the US can result in outbreaks that harm vulnerable populations, as herd immunity wanes under the influence of anti-vaccine sentiment [2]. Measles outbreaks often occur when infectious individuals enter into largely unvaccinated populations. This was the case in the 2019 New York outbreak, where several infected travelers carried measles into orthodox Jewish neighborhoods with low school immunization rates, resulting in hundreds of epidemiologically linked cases [4]. Even a single infected traveler can spark a significant outbreak—a recent 71-case outbreak near

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Conclusion