Abstract
Plasmablastic lymphoma (PBL) is a rare form of diffuse large B-cell lymphoma characterized by weak/absent expression of conventional B-cell markers and strong expression of plasma cell markers. It is strongly associated with human immunodeficiency virus (HIV) and Epstein Barr virus infection, and shows an unusual tropism to the oral cavity. Herein we describe a patient with AIDS who presented with weight loss and dysphagia owing to a large gastroesophageal mass. His radiographic and endoscopic findings and long history of cigarette consumption suggested carcinoma. Biopsy demonstrated a poorly differentiated tumor stained negatively to routine lymphoid markers including CD20. However, gene rearrangement studies confirmed a B-cell process and a more detailed immunohistochemical analysis revealed the cells stained positively for CD138 (plasma cell antigen). These findings were diagnostic of PBL. Our report reviews the wide differential diagnosis of PBL and underscores the importance of a broad array of viral and molecular studies needed to establish this diagnosis.
Highlights
phlettmpe:/n/wt>wmeePnrtorcale.ceodmin/gcsoonftethnet/p1d1ft/h17In5t0e-r9n3a7ti8o-n4a-Sl 2C-oinnfofe.prednf MAIDS and Other Acquired Immunodeficiencies (ICMAOI): Basic, Epidemiologic, and Clinical Research Publication of this supplement was made possible with support from the Office of HIV and AIDS Malignancy, National Cancer Institute, National Institutes of Health. Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
We describe a patient with AIDS who presented with weight loss and dysphagia owing to a large ulcerative gastroesophageal mass
These findings were diagnostic of Plasmablastic lymphoma (PBL) and the patient was treated with combination chemotherapy consisting of liposomal doxorubicin, cyclophosphamide and etoposide
Summary
phlettmpe:/n/wt>wmeePnrtorcale.ceodmin/gcsoonftethnet/p1d1ft/h17In5t0e-r9n3a7ti8o-n4a-Sl 2C-oinnfofe.prednf MAIDS and Other Acquired Immunodeficiencies (ICMAOI): Basic, Epidemiologic, and Clinical Research Publication of this supplement was made possible with support from the Office of HIV and AIDS Malignancy, National Cancer Institute, National Institutes of Health. Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.. AIDS-associated plasmablastic lymphoma presenting as a poorly differentiated esophageal tumor: a diagnostic dilemma * Corresponding author from 11th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI): Basic, Epidemiologic, and Clinical Research Bethesda, MD, USA.
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