Abstract

Some tumor types are related to HIV, including non-Hodgkin lymphoma (NHL). The morbidity and mortality of NHL has remained high, even after highly active antiretroviral therapy (HAART) was introduced. We collected cases of AIDS with NHL, and evaluated the imaging features and strategies for diagnosis. There were 27 patients with AIDS and tumors confirmed by pathology. There were 9 patients with Burkitt lymphoma, 16 with diffuse large B cell lymphomas (DLBCLs), and 2 with primary central nervous system (PCNS) lymphomas. All of the patients underwent a series of imaging studies. Three radiologists analyzed the images, and any disagreement was discussed until consensus was reached. The radiologic manifestations of AIDS with NHL were mainly masses and lymphadenopathy, 3 patients having one mass and 12 two or more masses. 7 patients had lymphadenopathy in one site and 3patients had lymphadenopathy in two or more sites. Coarse mucosal folds, thickening of the gastrointestinal wall, and lumen narrowing were typical manifestations of NHL within the gastrointestinal tract. There were 4 patients with masses and 5 with lymphadenopathy inthe 9 with Burkitt lymphoma, and 11 patients with masses 5 with lymphadenopathy in the 16 with DLBCLs. NHL is a malignancy that usually occurs in patients with AIDS. Imaging is an important method by which to evaluate lesions, masses, and lymphadenopathy. Fine needle aspiration biopsy and stereotaxis biopsy are useful methods by which to diagnose NHL.

Highlights

  • The main clinical manifestation of acquired immunodeficiency syndrome (AIDS) is a negative impact on the immune system

  • Some tumor types are related to HIV, including non-Hodgkin lymphoma (NHL)

  • There were 27 patients with AIDS and tumors confirmed by pathology, 12 of whom were diagnosed by fine needle aspiration biopsy

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Summary

Introduction

The main clinical manifestation of acquired immunodeficiency syndrome (AIDS) is a negative impact on the immune system. Since the beginning of the HIV epidemic in the 1980s, cancer has been prominent in the spectrum of immunodeficiency-related manifestations. The availability of highly active antiretroviral therapy (HAART) in 1996 has led to improvements in immune function, but without a corresponding decline in AIDS-related morbidity and mortality (Polesel et al.,2 008; Chun et al, 2010; Beaudrap et al, 2013, Mendes Luz et al, 2014). Results: The radiologic manifestations of AIDS with NHL were mainly masses and lymphadenopathy, 3 patients having one mass and 12 two or more masses. There were 4 patients with masses and 5 with lymphadenopathy inthe 9 with Burkitt lymphoma, and 11 patients with masses 5 with lymphadenopathy in the 16 with DLBCLs. Conclusion: NHL is a malignancy that usually occurs in patients with AIDS. Fine needle aspiration biopsy and stereotaxis biopsy are useful methods by which to diagnose NHL

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