Abstract
The ability to activate compensatory mechanisms in response to environmental stress is an important factor for survival and maintenance of cellular functions. A system that is often activated both in short and prolonged stress conditions is autophagy. Autophagy is required to clear the cell from dysfunctional organelles and altered proteins and is reported to decline during diseases or ageing. This reduction might contribute to the pathogenesis of organ dysfunction and, in general, to ageing. Here I will present the last data about the role of autophagy in organelle and protein turnover in skeletal muscles and the pathogenetic implications of deregulated autophagy in muscle disorders. Moreover, I will describe the importance of autophagy in physical performance and in exercise-dependent metabolic adaptations.
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