Abstract

Advances in artificial intelligence (AI) and synthetic biology have profoundly influenced biomedical research, creating transformative opportunities in imaging, diagnostics, and therapeutic engineering. In biomedical imaging, AI-driven algorithms enhance precision and accuracy, enabling automated analysis of complex datasets, real-time imaging insights, and identification of disease biomarkers. Meanwhile, synthetic biology redefines cellular engineering, particularly in T-cell research, by enabling customized functionalities, such as precision-targeted antigen recognition and tunable immune responses. The integration of AI into T-cell engineering amplifies these capabilities, facilitating the design and optimization of synthetic circuits, predictive modeling of cellular behaviors, and dynamic monitoring of therapeutic outcomes. This interdisciplinary approach is revolutionizing diagnostics and immunotherapy by streamlining the identification of disease-specific markers, improving diagnostic accuracy, and enabling real-time modulation of T-cell functionality within the tumor microenvironment. By combining AI-powered insights with synthetic biology's ability to engineer living systems, this research aims to address critical challenges in disease treatment, including tumor heterogeneity and immune evasion. This work explores the synergistic application of AI and synthetic biology in biomedical imaging and T-cell engineering, highlighting state-of-the-art technologies, their therapeutic potential, and the future landscape of personalized medicine.

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