Abstract
Background Food allergy is an increasing health problem. We and others have shown that the intensity of food allergic reactions can be regulated by regulatory T (Treg) cells. In addition, others have shown that activation of the aryl hydrocarbon receptor (AhR) is able to induce Treg cells. Here, we investigated whether activation of the AhR could suppress food allergic responses through the induction of Treg cells in a mouse peanut allergy model.
Highlights
Food allergy is an increasing health problem
A dose of 15 μg/kg BW TCDD caused a decrease in levels of peanut extract (PE)-specific IgE, IgG1 and IgG2a, mast cell degranulation and PE-induced IL-5, IL-10 and IL-13) and an increase in the percentage of CD4 +CD25+Foxp3+ Treg cells
The suppressive effect of aryl hydrocarbon receptor (AhR) activation on the peanut allergic response was reversed in the absence of CD4+CD25+Foxp3+ Treg cells
Summary
Food allergy is an increasing health problem. We and others have shown that the intensity of food allergic reactions can be regulated by regulatory T (Treg) cells. Others have shown that activation of the aryl hydrocarbon receptor (AhR) is able to induce Treg cells. We investigated whether activation of the AhR could suppress food allergic responses through the induction of Treg cells in a mouse peanut allergy model
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