Abstract
To the Editor.— Rare reports have associated neutropenia with prolonged administration of cephalothin. 1 We have recently had a patient with agranulocytosis caused by relatively low doses of cephalosporin antibiotics. Report of a Case.— A 44-year-old man had difficulty voiding and symptoms of myxedema. Results of the physical examination revealed typical signs of hypothyroidism. There were no palpable lymph nodes or other abnormalities. His hematocrit reading was 45% and white blood cell (WBC) count was 7,700/cu mm with a normal differential. Urinalysis showed no protein, sugar, bacteria, or cells. Radioactive iodine uptake and serum thyroxine content were well below normal. Serum cholesterol level was 359 mg/100 ml; blood urea nitrogen level, 15 mg/100 ml; and the creatinine level was 1.3 mg/100 ml. Chest roentgenogram was normal, and the electrocardiogram showed T-wave flattening. He was treated with desiccated thyroid starting at 0.16 mg/day. A week after admission he developed a dental
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