Abstract
There is a significant demand for antibiofilm and antimicrobial materials in the medical device industry. It is well established that Ag-based compounds have a high antimicrobial efficiency. Without being in a lattice, silver’s antimicrobial action is mainly mediated by the release of Ag + ions from the compound. These ions at high levels are toxic to most bacterial species. However, rapidly released Ag + ions tend to aggregate and lose their antibacterial effect over time. Thus, utilizing a new approach for using silver as an antimicrobial agent based on imparting the antimicrobial action through contact, rather than releasing Ag + ions could be beneficial. Here we report that Ag + ions intercalation of Tm/Er co-doped layered perovskites and their 2D nanosheets exhibit antibacterial and antibiofilm activities against the human opportunistic pathogens Escherichia coli and Bacillus subtilis. Specifically, flocculation of nanosheets with Ag + ions had efficient antibacterial and antibiofilm activity at 100 µg/mL. In addition, the flocculated product demonstrated low in vitro cytotoxicity against the Huh7 hepatocellular carcinoma cell line and HEK 293 embryonic kidney cell line. Our results indicate that Ag-intercalated layered perovskites and the flocculation of the nanosheets hold great promise to be used for antimicrobial and antibiofilm purposes in biomedical engineering applications.
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