Abstract
[ 3HSpiroperidol and [ 3H](−)-sulpiride specific binding have been used to assay for D 1 and D 2 dopaminergic recognition sites in striatal membranes of aged rats. While [ 3H]spiroperidol binding shows a decreased number of binding sites, no changes have been detected in [ 3H](−)-sulpiride binding, which is a marker for D 2 dopaminergic receptors. Data obtained with GTP and DA-dependent adenylyl cyclase activity confirm the hypothesis that aging selectively affects in rats those dopaminergic receptors coupled to the formation of cyclic AMP (D 1).
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