Abstract
Poststroke seizures and epilepsy have been described in numerous clinical and epidemiological studies over many years. In contrast, the pathophysiological events occurring in injured brain that establish poststroke epileptogenesis and epilepsy have had limited study in animal models. However, during the last several years, various models of ischemia (combined with video-EEG recordings) have contributed to a significantly improved understanding of the progressive biochemical, anatomical, and physiological changes associated with both early and late seizures following stroke. Because this area of research continues to be relatively under-explored, it provides numerous opportunities for new investigations.
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