Aging of healthy humans is associated with a decreased expression of the IGF-1R and FOXO1 genes and with altered expression of their interacting miRNAs

Abstract

Results.–Nonagenarians had the same ADL scores as octogenarians but their IADL scoreswere higher (P=0.040). In univariate analyses, nonagenarians showed significative decrease in TREC compared to octogenarians (113.5±18.4 vs. 180.5±26.5, P<0.05). Therewas no significant difference in telomere length (40.3±2.1 vs. 43.5±1.8, P=0.25). Key conclusions.– Our data show that nonagenarians present telomere length and TREC with minimal decrease compared to octogenarians. The nonagenarians could be more robust regarding a better oxidative status and a slower decrease of their telomere and TREC number. Further research including a larger and more representative sample of patients is needed to confirm these data.