Abstract
Resistance to collagenase digestion was used to compare rates of collagen aging in rat, dog, macaque, and man. The apparent rates were different for each species. Rat collagen was uniformly and readily digested, even at low calcium ion concentration where human collagen is digested slowly. Dog, macaque and human collagens all showed evidence of a progressive, age-related, increased stabilization. Some older dog specimens showed a much greater extent of stabilization than human specimens of the same chronological age, but similar if relative lifespans are used. These results demonstrate the problems caused by uncritically extrapolating an age-related observation from a short-lived species such as rat to a long-lived species such as human.
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