Abstract
Aging is considered to be a decline in physical and physiological events that extensively affect the body's immunity, and is linked with deterioration in both innate and adaptive immune responses. The immune system exhibits profound age-associated variations, known as immunosenescence, comprising a significantly low production of B and T lymphocytes in bone marrow and thymus, a decreased function of mature lymphocytes in secondary lymphoid tissues, a decrease in the synthesis of fresh naïve T cells, and reduced activation of T cells. Elderly individuals face a greater risk for many diseases particularly respiratory diseases due to their poor response to immune challenges as vigorously as the young. The current review explored the aging immune system, highlight the mortality rates of severe lung complications, such as pneumonia, COVID-19, asthma, COPD, lung cancer, IPF, and acute lung injury, and their correlation with aging immunity. This study can be helpful in better understanding the pathophysiology of aging, immune responses, and developing new approaches to improve the average age of the elderly population.
Highlights
Aging Immune System and Its Correlation With Liability to SevereAging is considered to be a decline in physical and physiological events that extensively affect the body’s immunity, and is linked with deterioration in both innate and adaptive immune responses
Health systems around the world are facing major challenges due to global demographic fluctuations
Inflammatory cytokines, which may be produced by stroma, dendritic cells (DCs), or aged B and T lymphocytes are present in higher concentrations in the tissue microenvironment [20]
Summary
Aging is considered to be a decline in physical and physiological events that extensively affect the body’s immunity, and is linked with deterioration in both innate and adaptive immune responses. Individuals face a greater risk for many diseases respiratory diseases due to their poor response to immune challenges as vigorously as the young. The current review explored the aging immune system, highlight the mortality rates of severe lung complications, such as pneumonia, COVID19, asthma, COPD, lung cancer, IPF, and acute lung injury, and their correlation with aging immunity. This study can be helpful in better understanding the pathophysiology of aging, immune responses, and developing new approaches to improve the average age of the elderly population
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