Abstract
In order to examine age-related changes in long-trace conditioning, five age groups (0.25, 1, 1.5, 2, and 2.5 years) of Wistar-derived female albino rats were subjected to taste-aversion conditioning at one of five conditioned stimulus–unconditioned stimulus (CS–US) intervals (0, 45, 90, 180, and 360 min). Age differences in the strength of the aversion were evident at CS–US intervals greater than 0 min and the strength of the aversion was directly related to age. An aversion was conditioned in only the two oldest age groups when the CS–US interval was 360 min. The age differences in taste-aversion and the superior long-trace conditioning in old-age rats were attributed to factors that accompany aging, for example, the gradual slowing down of a metabolic pacemaker.
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