Abstract

Histological surveys of the brains of guppies throughout their lifespan showed no overall loss of tissue with advancing age. Brain and body increased in size at a similar rate throughout adult life in male fish. In old females after the age of two years, brain growth apparently ceased, although body growth continued at a low rate. In both sexes there was a loss of neurones from the stratum griseum periventriculare in the midbrain roof in old age; the decrease in size was significant. The midbrain is a major correlative center concerned with spatial orientation. How far neuronal loss may contribute to functional behavioral disorder in old age is unknown, but a loss of orientation could render the older fish more susceptible to predation.

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