Abstract
Both endogenous and exogenous factors cause skin aging. This study aimed to compare the differential expressions of collagen type I (COL I) and collagen type VI (COL VI) in skins with biological aging and photoaging. In order to comprehend the impact of solar radiation in the dermis and the expression of COL I and COL VI, we studied the expression and their detection in healthy skin and in skin that had been characterized by aging. The hematoxylin and eosin staining protocol was performed in tissue paraffin blocks and they were then stained immunohistochemically with rabbit monoclonal anti-COL I and anti-COL VI antibodies. A total of 201 slides were studied with an Olympus BX 41 microscope, and the expressions of COL I and COL VI in the dermis were scored on a scale of 1 to 5, and then positively and statistically analyzed with IBM SPSS Statistics software. The results show that solar elastosis changes the structure of the skin’s collagen and solar elastosis was observed in the skin tissues with photoaging without appearing to be affected by its appearance in relation to age. Solar radiation divides the collagen fibers more rapidly than normal biological aging and replaces the collagen fibers of the skin. COL I and COL VI are expressed differently along the dermis of healthy skin tissue and the skin tissue subject to photoaging.
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