AGGRESSIVE DIFFUSE LARGE B-CELL LYMPHOMA IN ANTERIOR MAXILLARY REGION: CASE REPORT

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma and is rarely seen in the maxillofacial region. A case of DLBCL in a 50-year-old man who is immunocompetent (no reagent HIV-1 and -2, and human T-cell lymphotropic virus tests) is reported. The patient complained of a painful and aberrant mass in the anterior maxillary region with fast growing in 2 months. A facial computed tomography (CT) shows a large mass with soft tissue density, measuring approximately 7.4 × 6.6 cm, which invaded and destroyed the maxillary bone. The incisional biopsy showed an undifferentiated malignant neoplasm compatible with lymphoma. Immunohistochemical analysis proved the lesion to be a DLBCL, strongly positive for CD20 and CD79 a, weakly positive for VS38 c+ and Bc16 e MUM1, and negative for CD3, cyclin A D1, CD7, C43, CD10, B CD30, and CS1-4. The proliferation index, as indicated by Ki-67 immunohistochemistry, was over 80%. The patient was referred for oncological treatment. Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma and is rarely seen in the maxillofacial region. A case of DLBCL in a 50-year-old man who is immunocompetent (no reagent HIV-1 and -2, and human T-cell lymphotropic virus tests) is reported. The patient complained of a painful and aberrant mass in the anterior maxillary region with fast growing in 2 months. A facial computed tomography (CT) shows a large mass with soft tissue density, measuring approximately 7.4 × 6.6 cm, which invaded and destroyed the maxillary bone. The incisional biopsy showed an undifferentiated malignant neoplasm compatible with lymphoma. Immunohistochemical analysis proved the lesion to be a DLBCL, strongly positive for CD20 and CD79 a, weakly positive for VS38 c+ and Bc16 e MUM1, and negative for CD3, cyclin A D1, CD7, C43, CD10, B CD30, and CS1-4. The proliferation index, as indicated by Ki-67 immunohistochemistry, was over 80%. The patient was referred for oncological treatment.