Abstract
The influence of p-chlorophenylalanine (PCPA) and dihydroxyphenylalanine (DOPA) on aggressiveness elicited by marihuana in starved rats was studied. PCPA and DOPA potentiated several-fold this behavioural manifestation; the potentiation was still greater when the animals received both drugs. On the other hand, PCPA and DOPA alone or in combination, but without marihuana, failed to elicit aggressive behaviour in starved rats. Aggressiveness did not appear when rats fed ad libitum were treated with PCPA, DOPA and marihuana. The role played by starvation, PCPA and DOPA on the capability of marihuana to induce aggressive behaviour in rats is discussed.
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